Epidemiology of Azole-Resistance and CYP51A Mutations in Aspergillus Isolates Recovered from Lung Transplant Recipients Who Received Voriconazole Prophylaxis
نویسندگان
چکیده
منابع مشابه
Rate of cyp51A mutation in Aspergillus fumigatus among lung transplant recipients with targeted prophylaxis.
OBJECTIVES The most common mechanism of azole (itraconazole and voriconazole) resistance in Aspergillus fumigatus is a mutation at the cyp51A locus. The aim of our study was to determine the rate of cyp51A mutations in lung transplant recipients (LTR) undergoing targeted antifungal prophylaxis with 12 weeks of voriconazole. METHODS We conducted a prospective study that included 22 LTR with A....
متن کاملMultiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.
Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the TR34/L98H mutation. To our knowledge, the latter has not been found previousl...
متن کاملcyp51A-based mechanisms of Aspergillus fumigatus azole
72 Since the mid-1990s, a steady increase in the occurrence of itraconazole resistant Aspergillus 73 fumigatus isolates has been observed in clinical contexts leading to therapeutic failure in the 74 treatment of aspergillosis. This increase has been predominantly linked to a single allele of 75 the cyp51A gene, termed ‘TR/L98H’ which is thought to have arisen through the use of 76 agricultural...
متن کاملVoriconazole as secondary antifungal prophylaxis in stem cell transplant recipients.
A recently published editorial by Dr. Girmenia addressed the difficult issue of preventing invasive fungal disease in hematology patients. The author concluded that several questions remained unanswered concerning the use of secondary antifungal prophylaxis in this setting. We agree with Dr. Girmenia that most previous reports on secondary antifungal prophylaxis were retrospective, uncontrolled...
متن کاملBioavailability and population pharmacokinetics of voriconazole in lung transplant recipients.
This study was undertaken to characterize the pharmacokinetics and bioavailability of voriconazole in adult lung transplant patients during the early postoperative period, identify factors significantly associated with various pharmacokinetic parameters, and make recommendations for adequate dosing regimens. Thirteen lung transplant patients received two intravenous infusions (6 mg/kg, twice da...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2016
ISSN: 2328-8957
DOI: 10.1093/ofid/ofw172.1554